2023
Lam, Maggie P Y
Seeking clarity on sex differences in cardiovascular complications of Down syndrome Miscellaneous
2023, ISSN: 1522-1539.
@misc{pmid37115628,
title = {Seeking clarity on sex differences in cardiovascular complications of Down syndrome},
author = {Maggie P Y Lam},
doi = {10.1152/ajpheart.00210.2023},
issn = {1522-1539},
year = {2023},
date = {2023-06-01},
journal = {Am J Physiol Heart Circ Physiol},
volume = {324},
number = {6},
pages = {H863--H865},
keywords = {},
pubstate = {published},
tppubtype = {misc}
}
2021
Han, Yu; Li, Lauren Z; Kastury, Nikhitha L; Thomas, Cody T; Lam, Maggie P Y; Lau, Edward
Transcriptome features of striated muscle aging and predictability of protein level changes Journal Article
In: Mol Omics, vol. 17, no. 5, pp. 796–808, 2021, ISSN: 2515-4184.
@article{pmid34328155,
title = {Transcriptome features of striated muscle aging and predictability of protein level changes},
author = {Yu Han and Lauren Z Li and Nikhitha L Kastury and Cody T Thomas and Maggie P Y Lam and Edward Lau},
doi = {10.1039/d1mo00178g},
issn = {2515-4184},
year = {2021},
date = {2021-10-01},
journal = {Mol Omics},
volume = {17},
number = {5},
pages = {796--808},
abstract = {We performed total RNA sequencing and multi-omics analysis comparing skeletal muscle and cardiac muscle in young adult (4 months) early aging (20 months) mice to examine the molecular mechanisms of striated muscle aging. We observed that aging cardiac and skeletal muscles both invoke transcriptomic changes in innate immune system and mitochondria pathways but diverge in extracellular matrix processes. On an individual gene level, we identified 611 age-associated signatures in skeletal and cardiac muscles, including a number of myokine and cardiokine encoding genes. Because RNA and protein levels correlate only partially, we reason that differentially expressed transcripts that accurately reflect their protein counterparts will be more valuable proxies for proteomic changes and by extension physiological states. We applied a computational data analysis workflow to estimate which transcriptomic changes are more likely relevant to protein-level regulation using large proteogenomics data sets. We estimate about 48% of the aging-associated transcripts predict protein levels well ( ≥ 0.5). In parallel, a comparison of the identified aging-regulated genes with public human transcriptomics data showed that only 35-45% of the identified genes show an age-dependent expression in corresponding human tissues. Thus, integrating both RNA-protein correlation and human conservation across data sources, we nominate 134 prioritized aging striated muscle signatures that are predicted to correlate strongly with protein levels and that show age-dependent expression in humans. The results here reveal new details into how aging reshapes gene expression in striated muscles at the transcript and protein levels.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
We performed total RNA sequencing and multi-omics analysis comparing skeletal muscle and cardiac muscle in young adult (4 months) early aging (20 months) mice to examine the molecular mechanisms of striated muscle aging. We observed that aging cardiac and skeletal muscles both invoke transcriptomic changes in innate immune system and mitochondria pathways but diverge in extracellular matrix processes. On an individual gene level, we identified 611 age-associated signatures in skeletal and cardiac muscles, including a number of myokine and cardiokine encoding genes. Because RNA and protein levels correlate only partially, we reason that differentially expressed transcripts that accurately reflect their protein counterparts will be more valuable proxies for proteomic changes and by extension physiological states. We applied a computational data analysis workflow to estimate which transcriptomic changes are more likely relevant to protein-level regulation using large proteogenomics data sets. We estimate about 48% of the aging-associated transcripts predict protein levels well ( ≥ 0.5). In parallel, a comparison of the identified aging-regulated genes with public human transcriptomics data showed that only 35-45% of the identified genes show an age-dependent expression in corresponding human tissues. Thus, integrating both RNA-protein correlation and human conservation across data sources, we nominate 134 prioritized aging striated muscle signatures that are predicted to correlate strongly with protein levels and that show age-dependent expression in humans. The results here reveal new details into how aging reshapes gene expression in striated muscles at the transcript and protein levels.
2019
Han, Yu; Wennersten, Sara A; Lam, Maggie P Y
Working the literature harder: what can text mining and bibliometric analysis reveal? Miscellaneous
2019, ISSN: 1744-8387.
@misc{pmid31822126,
title = {Working the literature harder: what can text mining and bibliometric analysis reveal?},
author = {Yu Han and Sara A Wennersten and Maggie P Y Lam},
doi = {10.1080/14789450.2019.1703678},
issn = {1744-8387},
year = {2019},
date = {2019-01-01},
journal = {Expert Rev Proteomics},
volume = {16},
number = {11-12},
pages = {871--873},
keywords = {},
pubstate = {published},
tppubtype = {misc}
}
2018
Lam, Maggie P Y; Ge, Ying
Harnessing the Power of Proteomics to Assess Drug Safety and Guide Clinical Trials Miscellaneous
2018, ISSN: 1524-4539.
@misc{pmid29506994,
title = {Harnessing the Power of Proteomics to Assess Drug Safety and Guide Clinical Trials},
author = {Maggie P Y Lam and Ying Ge},
doi = {10.1161/CIRCULATIONAHA.117.032876},
issn = {1524-4539},
year = {2018},
date = {2018-03-01},
journal = {Circulation},
volume = {137},
number = {10},
pages = {1011--1014},
abstract = {Assessing drug safety and efficacy is costly, and many promising candidates can present unwanted side effects. Can new developments in proteomic biomarkers help provide timely monitoring of efficacy and protect participant safety? In this issue, Williams tackled this question with a retrospective study on whether patients treated with torcetrapib in the ILLUMINATE trial showed signs of increased cardiovascular risks early in the trial.},
keywords = {},
pubstate = {published},
tppubtype = {misc}
}
Assessing drug safety and efficacy is costly, and many promising candidates can present unwanted side effects. Can new developments in proteomic biomarkers help provide timely monitoring of efficacy and protect participant safety? In this issue, Williams tackled this question with a retrospective study on whether patients treated with torcetrapib in the ILLUMINATE trial showed signs of increased cardiovascular risks early in the trial.
2015
Lam, Maggie P Y; Venkatraman, Vidya; Cao, Quan; Wang, Ding; Dincer, T Umut; Lau, Edward; Su, Andrew I; Xing, Yi; Ge, Junbo; Ping, Peipei; Eyk, Jennifer E Van
Prioritizing Proteomics Assay Development for Clinical Translation Miscellaneous
2015, ISSN: 1558-3597.
@misc{pmid26160638,
title = {Prioritizing Proteomics Assay Development for Clinical Translation},
author = {Maggie P Y Lam and Vidya Venkatraman and Quan Cao and Ding Wang and T Umut Dincer and Edward Lau and Andrew I Su and Yi Xing and Junbo Ge and Peipei Ping and Jennifer E Van Eyk},
doi = {10.1016/j.jacc.2015.04.072},
issn = {1558-3597},
year = {2015},
date = {2015-07-01},
journal = {J Am Coll Cardiol},
volume = {66},
number = {2},
pages = {202--204},
keywords = {},
pubstate = {published},
tppubtype = {misc}
}
2013
Lam, Maggie P Y; Lau, Edward; Liem, David A; Ping, Peipei
Cyclophilin D and acetylation: a new link in cardiac signaling Miscellaneous
2013, ISSN: 1524-4571.
@misc{pmid24311610,
title = {Cyclophilin D and acetylation: a new link in cardiac signaling},
author = {Maggie P Y Lam and Edward Lau and David A Liem and Peipei Ping},
doi = {10.1161/CIRCRESAHA.113.302687},
issn = {1524-4571},
year = {2013},
date = {2013-12-01},
journal = {Circ Res},
volume = {113},
number = {12},
pages = {1268--1269},
keywords = {},
pubstate = {published},
tppubtype = {misc}
}