# Maggie Lam Lab ## Posts - [Cake First, Worries Later](https://maggielamlab.org/cake-first-worries-later/): After weeks of editing, gallons of coffee, and some very intense science moments, our pre-/post-doc AHA grants were submitted this week. Great job, grant writers! Super proud of all of us. Bunch of thanks to Dominic, our lab manager who supported everybody and helped us survive this. While the results are still months away, we think we all deserve some cakes! - [NHLBI R01 Renewal Application Receives 14th Percentile](https://maggielamlab.org/exploring-the-innovative-work-of-maggie-lam-lab/): We look forward to continuing our work on protein alternative splicing and examine how splice variants affect proteostasis in cardiac diseases. Fingers Crossed! - [BioArXiV article on Gene Annotation Bias](https://maggielamlab.org/bioarxiv-article-on-gene-annotation-bias/): We previously published a data science method PubPular to calculate the co-occurrence of genes and queried topics on PubMed articles, and suggested that normalized co-publication distance (NCD) may be used as a metric to discover the connection its between a gene/protein and a disease or physiological process. A manuscript posted on the bioRxiv preprint server earlier this year examined how bibliometrics methods such as PubPular may be used to determine the state of gene annotation in biomedical research. The articles authored by Haynes, Tomczak and Khatri at Stanford University borrowed the Gini coefficient from economics to measure the inequality in […] - [Quantifying the Value of Basic Science](https://maggielamlab.org/trial/): In this era of constrained research funding, the value of basic research to the public is sometimes debated. Arguments are often advanced anecdotally: on the one hand well known example on the unpredictable later applicability of basic research abound, from CRISPR to modern innovations on smart phones, which built upon research in the 60s on transtistors which built upon quantum mechanisms from 100 years ago.  On the other hand, the value of basic research is doubted by a spectrum of individuals from the public to well meaning medical professionals who lament that not more research is oriented towards direct translation […] ## Pages - [Code + Data](https://maggielamlab.org/code-data/): Pubpular Proteins tool: https://heart.shinyapps.io/PubPular/ JCAST: https://ed-lau.github.io/jcast Protein Alternative Isoform: https://heart.shinyapps.io/data-splice-browser/ - [Lab Timeline](https://maggielamlab.org/timeline-2/) - [Table](https://maggielamlab.org/table/) - [Heatmap](https://maggielamlab.org/heatmap/) - [3D](https://maggielamlab.org/3d/) - [Our Story](https://maggielamlab.org/our-story/) - [Timeline](https://maggielamlab.org/timeline/) - [Publications](https://maggielamlab.org/publications/) - [Members](https://maggielamlab.org/members/): Current Lab Members Alumni - [Contact](https://maggielamlab.org/contact/): Contact Maggie Lam maggie.lam [at] cuanschutz.edu (303) 724-3520 Contact Us Visit our lab: Our Location Research Complex II 840012700 E. 19th AvenueAurora CO 80045 USA Get Directions 9am – 6pm Contact Us Get in touch with our Lab for collaborations or more information about our projects - [Research Projects](https://maggielamlab.org/research/): Alternative Splicing Alternative splicing allows a single gene to code for multiple proteins and greatly expands the diversity of the proteome. It is estimated that up to 95% of human genes undergo alternative splicing. Our genome is said to encompass ~20,400 protein coding genes but can produce up to 100,000 different protein species through alternative splicing. There are seven major types of alternative splicing events: skipped exon, mutually exclusive exons, retained intron, alternative 5′ splice site, alternative 3′ splice site, alternative promotor/first exon, and alternative poly-A site/ terminal exon. The Drosophila Dscam gene represents one of the most extreme cases […] - [About](https://maggielamlab.org/about/): Maggie Lam Welcome to Maggie Lam Lab, where creativity meets innovation in our unique projects. We focus on excellence. Our Mission Driven by passion. Creative Lab Established in 2023 We focus on excellence. Our Vision Innovative Space Future of creativity We envision a future where our innovative solutions transform industries and empower individuals. Maggie Lam Lab At Maggie Lam Lab, we are dedicated to innovative solutions and exceptional service, striving to exceed expectations in every project we undertake. Maggie Lam Explore the captivating works and innovative creations of Maggie Lam Lab’s artistic vision. - [Home](https://maggielamlab.org/): From Molecules to Nature Mass Spectrometry We leverage mass spectrometry and proteomics alongside other technologies to study complex systems across biological and biomedical sciences. Proteomics Our current resesarch projects include method development in multiple areas of proteomics, the study of posttranscriptional regulation (e.g., alternative splicing), as well as glycoproteomics and ER stress. Lab Blog and News [comment]: # (Generated by Hostinger Tools Plugin)